► Andronas, N., Karageorgiou, E., Beratis, I., Fragkiadaki, S., Kontaxopoulou, D., Yannis, G., Stefanis, L., & Papageorgiou, S. (2022). Predicting behind-the-wheel driving behavior in PD through motor and cognitive testing in outpatient clinics (P14-3.004) [Abstract]. Neurology, 98(18 Suppl.), Article 2574. https://tinyurl.com/526vtdtu
Objective:
Objective of this study was to investigate whether specific motor and cognitive tests performed in clinic can predict behind-the-wheel driving behavior (DB) in Parkinson’s disease (PD).
Conclusions:
Motor and cognitive phenotypes derived from daily clinical practice can help predict behind-the-wheel DB in PD, allowing guidance on which patients should undergo formal assessments and who may need to stop driving.
► Koros, C., Beratis, I., Matsi, S., Bougea, A., Bonakis, A., Papatriantafyllou, I., Angelopoulou, E., Kapaki, E., Stefanis, L., & Papageorgiou, S. G. (2022). Prosopagnosia, other specific cognitive deficits, and behavioral symptoms: Comparison between right temporal and behavioral variant of frontotemporal dementia. Vision, 6(4), Article 75. https://doi.org/10.3390/vision6040075
Right temporal variant of frontotemporal dementia (rtv-FTD) represents an uncommon and recently described frontotemporal dementia (FTD) entity presenting with symptoms in many ways comparable to those of the frontal or behavioral variant of FTD (bv-FTD). The aims of this study were to explore the timing of cognitive and behavioral symptoms of rtv-FTD, and to compare the distinct cognitive deficits including prosopagnosia and behavioral symptoms of rtv-FTD patients with those observed in bv-FTD patients. We reviewed the records of 105 patients clinically diagnosed with FTD. A total of 7 patients (5 men/2 women) with FTD and marked right temporal atrophy in magnetic resonance imaging (MRI) were detected. Clinical features were compared with those observed in a group of 22 age-matched patients (16 men/6 women) with FTD and predominant frontal lobe atrophy. The main presenting symptoms of rtv-FTD were prosopagnosia, apathy, and episodic memory impairment. In contrast, social awkwardness and compulsive behaviors were dominant in later stages of the disease together with disinhibition and loss of insight with a marked personality change. Although the cognitive and behavioral profiles of patients with right temporal or frontal lobes atrophy present substantial similarities, each subtype has a number of distinct characteristics. It appears that prosopagnosia, obsessive behaviors, and psychotic symptoms are more prominent in rtv-FTD patients.
► Mougias, M., Beratis, I. N., Moustaka, K., Alexopoulos, P., & Assimakopoulos, K. (2023). The differential role of executive apathy in Alzheimer’s disease dementia, mild cognitive impairment and healthy cognitive ageing. Geriatrics, 8(2), Article 38. https://doi.org/10.3390/geriatrics8020038
The objective of the present work was to compare the levels of executive, emotional, and initiation apathy in individuals with mild cognitive impairment (MCI), mild Alzheimer’s disease dementia (ADD), and cognitively intact healthy controls (HCs). Fifty-two patients with mild ADD, 40 individuals with MCI, and 37 cognitively intact individuals were included in the current study. The participants were consecutive visitors to the Outpatient Memory Clinic of “Nestor” Alzheimer’s Center. The symptoms of apathy were measured with the dimensional apathy scale. Analyses showed that ADD patients had significantly higher degrees of executive, emotional, initiation, and overall apathy compared with both the MCI group and the HCs. Additionally, a significant difference was observed in the dimension of executive apathy between individuals with MCI and the HCs. In conclusion, the dimension of executive apathy was the most sensitive measure regarding the differentiation of individuals with mild ADD or MCI and HCs. Hence, detailed evaluation of executive apathy in older individuals referred to a memory clinic may provide useful information contributing to their diagnostic categorization and to the differentiation between neurocognitive disorders and healthy cognitive ageing.
► Papastefanopoulou, V., Stanitsa, E., Koros, C., Simoudis, A., Florou-Hatziyiannidou, C., Beratis, I., Antonelou, R., Andronas, N., Voskou, P., Angelopoulou, E., Papatriantafyllou, J. D., Stefanis, L., Kroupis, C., & Papageorgiou, S. G. (2023). APOE allele frequency in Southern Greece: Exploring the role of geographical gradient in the Greek population. Geriatrics, 8(1), Article 1. https://doi.org/10.3390/geriatrics8010001
Background: the apolipoprotein e4 allele (APOE4) constitutes an established genetic risk factor for Alzheimer’s Disease Dementia (ADD). We aimed to explore the frequency of the APOE isoforms in the Greek population of Southern Greece. Methods: peripheral blood from 175 Greek AD patients, 113 with mild cognitive impairment (MCI), and 75 healthy individuals. DNA isolation was performed with a High Pure PCR Template Kit (Roche), followed by amplification with a real-time qPCR kit (TIB MolBiol) in Roche’s Light Cycler PCR platform. Results: APOE4 allele frequency was 20.57% in the ADD group, 17.69% in the MCI group, and 6.67% in the control group. APOE3/3 homozygosity was the most common genotype, while the frequency of APOE4/4 homozygosity was higher in the AD group (8.60%). APOE4 carrier status was associated with higher odds for ADD and MCI (OR: 4.49, 95% CI: [1.90–10.61] and OR: 3.82, 95% CI: [1.59–9.17], respectively). Conclusion: this study examines the APOE isoforms and is the first to report a higher APOE frequency in MCI compared with healthy controls in southern Greece. Importantly, we report the occurrence of the APOE4 allele, related to ADD, as amongst the lowest globally reported, even within the nation, thus enhancing the theory of ethnicity and latitude contribution.
► Simitsi, A. M., Koros, C., Stamelou, M., Beratis, I., Efthymiopoulou, E., Papadimitriou, D., Bougea, A., Picillo, M., Stanitsa, E., Papagiannakis, N., Antonelou, R., Pachi, I., Papageorgiou, S. G., Barone, P., & Stefanis, L. (2022). Asymptomatic carriers of the p.A53T SNCA mutation: Data from the PPMI study [Correspondence]. Parkinsonism & Related Disorders, 98, 72–74. https://doi.org/10.1016/j.parkreldis.2022.04.001
We assessed non motor characteristics of 12 asymptomatic p.A53T mutation carriers (A53T-AC) compared with 36 healthy controls (HC) enrolled in the Parkinson's Progression Markers Initiative (PPMI) study. Olfaction score was lower and anxiety was marginally more prevalent in A53T- AC. These findings suggest distinct prodromal features in this group of subjects.